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| Hirohito and Empress Nagako with Richard Nixon and First Lady Pat Nixon in Anchorage, September 27, 1971 |
Monday, 27 July 2015
Hirohito
Monday, 9 June 2014
Alexander Fleming
NAME Sir Alexander Fleming
WHAT FAMOUS FOR Best known for his discovery of penicillin, the world's first broadly effective antibiotic substance. He also discovered lysozyme.
BIRTH Alexander Fleming was born on August 6, 1881, at Lochfield Farm near Darvel in Ayrshire, Scotland.
FAMILY BACKGROUND Fleming came from a farming family. He was the seventh of eight children and the third of four children from his father's second wife. His father, Hugh Fleming, was a Scottish hill farmer, and his mother was Grace Fleming. He had four half-siblings who were the surviving children from his father Hugh's first marriage.
CHILDHOOD Growing up in rural southwestern Scotland shaped Fleming's powers of observation and appreciation for the natural world at an early age. The Fleming children spent much of their of time ranging through the streams, valleys, and moors of the countryside. "We unconsciously learned a great deal from nature," said Fleming. (1)
EDUCATION Fleming's education began at Loudoun Moor School, followed by Darvel School and Kilmarnock Academy. In 1895, at the age of 14, he moved to London to live with his elder brother Thomas, who worked as an oculist. He completed his basic education at Regent Street Polytechnic (now the University of Westminster).
In 1901, Fleming began his medical studies at St. Mary's Hospital Medical School, funded by a scholarship and a legacy from his uncle. He excelled in his studies, winning the 1908 gold medal as the top medical student at the University of London.
CAREER RECORD 1897-1901 Worked for four years as a London shipping clerk.
1901-1908 Fleming initially planned to become a surgeon, but after working in a temporary position in the Inoculation Department at St. Mary's Hospital, he decided to pursue bacteriology instead. He became assistant bacteriologist to Sir Almroth Wright, a pioneer in vaccine therapy and immunology.
1908-1914 After qualifying as a doctor, Fleming became a lecturer at St. Mary's until World War I.
1914-1918 Served in the Royal Army Medical Corps during World War I, studying wound infections.
1918-1928 Fleming returned to research and teaching at St. Mary's.
1928 -1948 Professor of Bacteriology at the University of London in 1928.
1948 Fleming retired with the title Emeritus Professor of Bacteriolog of University of London, but continued at St Marys as head of Wright-Fleming Institute of Biology.
1951-1954 Rector of Edinburgh University
APPEARANCE Sir Alexander Fleming was a Scottish man of average build, often depicted in photographs and portraits as a dignified older gentleman. In his later years, Fleming had thinning hair, a high forehead, and a composed, thoughtful expression. In the last years of his life, biographers noted that he appeared to age rapidly, with "red-rimmed eyes and trembling hands," giving him the appearance of an old man seemingly overnight. (2)
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| Fleming in his laboratory, c. 1943 |
FASHION Fleming's most distinctive fashion choice was his fondness for colorful bow ties, which he wore consistently throughout his career.
CHARACTER Fleming was described as a quiet, patient, and modest gentleman who was not given to displays of emotion. He possessed a natural shyness that made him avoid accolades and attention. He could be silent to the point of being inscrutable, making it difficult even for his wife and closest friends to gauge his moods and desires.
Though occasionally brusque and aloof, he was charming and gentle among friends and loved ones. His colleagues affectionately called him "Flem". Initially a shy, uncommunicative man and a poor lecturer, he blossomed under the attention he received later in life, becoming one of the world's best-known scientists.
SPEAKING VOICE Fleming was initially considered a poor lecturer. However, his communication skills improved significantly after he gained worldwide recognition, enabling him to become an effective ambassador for science and medicine.
SENSE OF HUMOUR His playful approach to science suggests Fleming maintained a certain lightheartedness. Sir Almorth Wright once told him, "You treat research like a game. You find it all great fun," to which Fleming agreed, saying, "I play with microbes. There are, of course, many rules to this play... but when you have acquired knowledge and experience it is very pleasant to break the rules and to be able to find something nobody had thought of". (3)
RELATIONSHIPS Alexander Fleming married Sarah Marion McElroy (nicknamed Sareen), an Irish nurse from Killala, County Mayo, on December 24, 1915. The wedding took place in London. The couple had one son, Robert Fleming, born in 1924, who followed his father into medicine and became a general practitioner.
After 34 years of marriage, Sareen died in 1949, which affected Fleming profoundly. Following her death, he buried himself in his work, spending longer hours in his laboratory behind closed doors.
In 1953, two years before his death, Fleming married Dr. Amalia Koutsouri-Vourekas, a Greek microbiologist on April 9, 1953. The civil ceremony was held at the Chelsea Register Office in London, followed by a second ceremony at the Greek Orthodox Church in Bayswater.
Amalia had been involved in the Greek resistance movement during World War II and had been Fleming's colleague since 1946, when she enrolled at St. Mary's Hospital on a scholarship.
MONEY AND FAME Fleming received numerous honors throughout his life, most notably being knighted in 1944 and sharing the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain.
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| Display of Fleming's awards, including his Nobel Prize. John - Wikipedia |
For the last decade of his life, he was celebrated universally for his discovery of penicillin and acted as a world ambassador for medicine and science. Initially uncomfortable with public attention due to his shy nature, he eventually blossomed under the recognition, becoming one of the world's best-known scientists.
In his Nobel Banquet speech in 1945, Fleming reflected on his newfound fame: "For many years I have read of people getting the Nobel Prize. Then I always regarded them as a superior class to which it was almost impossible to aspire. Now suddenly I find myself in that class and I wonder whether they are so different". (4)
MUSIC AND ARTS Fleming had a notable artistic side. He was a member of the Chelsea Arts Club, where he created watercolor paintings, though these were described as "amateurish". As a self-taught artist with no formal training, he painted what occurred to him, with his works lacking dimension or nuance but possessing a certain vigor.
More uniquely, Fleming created "germ art" by painting with bacteria that had different natural pigments. His bacterial art included images of ballerinas, houses, soldiers, mothers feeding children, and stick figures fighting. These living paintings would "breathe back" when breathed upon, as they contained living organisms.
He also crafted "mold medallions" as gifts by sealing mold grown on blotting paper between spare eyeglass lenses from his brother's ophthalmology practice. Notable recipients included the Queen of England, Churchill, Roosevelt, friends, colleagues, and many people he met during his travels.
Fleming was also an exceptional glass blower who custom-made laboratory apparatus for his own experiments. (2) (3)
LITERATURE Fleming wrote numerous scientific papers on bacteriology, immunology, and chemotherapy, including original descriptions of lysozyme and penicillin. His scientific writings were instrumental in documenting his discoveries and advancing the field of antibiotics.
NATURE Fleming's country upbringing in southwestern Scotland fostered his appreciation for the natural world from an early age. This early exposure to nature likely contributed to his powers of observation that would later prove crucial in his scientific discoveries.
HOBBIES AND SPORTS Fleming enjoyed a variety of recreational activities. He was a member of the London Scottish Regiment's rifle club, which actually influenced his career path when the captain convinced him to pursue research rather than surgery to keep him in the club.
He loved playing games of all sorts, including golf, checkers, quiz games, and billiards. This playful approach extended to his scientific work, which he often treated like a game. As noted earlier, his artistic pursuits included creating watercolors and bacterial artwork.
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| Image by Perplexity |
SCIENCE AND MATHS Fleming possessed a genius for technical ingenuity and original observation. His two major scientific discoveries were lysozyme in 1922 and penicillin in 1928.
His other contributions to science included conducting the first documented systematic study of nosocomial infection, introducing a black staining dye for bacteria known as nigrosin, and expressing early concerns about penicillin overuse leading to antibiotic resistance.
DISCOVERY OF PENICILLIN Picture, if you will, a slightly rumpled Scotsman named Alexander Fleming returning to his cluttered laboratory at St Mary’s Hospital after a modest seaside holiday—sunburnt nose, pockets full of sand, and, one imagines, a certain post‑vacation reluctance to face the mountain of dirty Petri dishes awaiting him. It was September 28, 1928, and the place smelled faintly of agar, over‑boiled tea, and whatever unfortunate microbes had expired in the name of science while Fleming was off eyeing gulls.
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| Image by Perplexity |
As he surveyed the carnage, Fleming noticed one particular dish of Staphylococcus aureus that looked curiously tidy. A rogue blob of greenish‑blue mould had plonked itself down in the middle, like an uninvited dinner guest, and every bacterial neighbour within shouting distance had disappeared—as if the mould had cleared its throat and said, “Right then, everyone out.” Around the intruder lay a perfect halo of nothingness, a microbial no‑man’s‑land. Lesser mortals might have tossed the plate in the bin; Fleming, blessed with an eye for the oddly important, peered closer and murmured something along the lines of, “Well, that’s jolly interesting.”
The mould turned out to be a species of Penicillium, and the invisible assassin it secreted was christened penicillin on March 7, 1929, a name Fleming coined with the breezy confidence of a man who had just stumbled on history’s greatest life‑saver while cleaning up after himself. He dutifully published a paper the same year—though, as was typical of Fleming, he did so in prose dry enough to desiccate a camel, ensuring that hardly anyone noticed for a good decade.
Before this happy accident, an infected splinter could book you a one‑way ticket to the pearly gates. Pneumonia, gonorrhoea, and rheumatic fever were less illnesses than grim inevitabilities. Penicillin, once coaxed into usable form, would change all that: suddenly doctors had a potion that sent bacteria scurrying for cover, and patients who might have expired on Tuesday were up and grumbling about hospital food by Friday.
There was, however, a snag. Fleming was a whiz at noticing things but hopeless at industrial chemistry. His early attempts to purify penicillin produced quantities measurable only in thimblefuls. Enter Howard Florey and Ernst Chain at Oxford, who, like pragmatic aunts tidying up after a brilliant but disorganised nephew, turned penicillin from lab curiosity into bona‑fide wonder drug in the early 1940s, just in time to keep untold numbers of Allied soldiers alive long enough to complain about army rations instead.
In 1945, the Nobel committee rounded up Fleming, Florey, and Chain and handed them the Physiology or Medicine prize, thereby acknowledging that a fortuitous spot of mould, a holiday hangover, and a lot of determined biochemistry had together delivered what some sober historians still call “the single greatest victory ever achieved over disease.”
Not bad for a chap who simply failed to tidy his lab before going to the beach.
PHILOSOPHY & THEOLOGY Alexander Fleming wasa devout Roman Catholic. His personal faith was well known among those who studied his life, and he is cited as an example of a major scientific figure who maintained a strong religious conviction while contributing to humanity’s understanding of the natural world.
Fleming’s life and work are often referenced in discussions about the relationship between science and religion. Some commentators have noted that his devout faith and scientific achievements challenge the notion that science and religion are inherently at odds. Fleming’s example demonstrates that one can be committed to both rigorous scientific inquiry and personal religious beliefs. (5)
Fleming’s discovery of penicillin is frequently discussed in philosophical debates about “moral luck”-the idea that chance events can play a significant role in scientific achievement. While the initial discovery of penicillin was serendipitous, Fleming’s scientific skills, powers of observation, and experimental rigor were crucial in recognizing its importance. Philosophers have used his case to explore questions of praiseworthiness and the role of luck versus skill in scientific innovation. (2)
Fleming cared deeply about the ethical implications of his discoveries. He believed that antibiotics like penicillin should be used freely for the benefit of humanity, not for profit. This perspective reflects a strong commitment to social responsibility and the greater good, aligning with both ethical and humanitarian principles.
POLITICS Fleming firmly believed that medical advances, such as penicillin, should be used "freely, not for profit, but for people" and was outspoken against the idea of pharmaceutical companies patenting or monopolizing penicillin for commercial gain. When he learned that U.S. pharmaceutical companies were attempting to patent the mass production method for penicillin, he protested:
“I found penicillin and have given it free for the benefit of humanity. Why should it become a profit-making monopoly of manufacturers in another country?”
His stance aligned with broader movements in mid-20th-century Britain advocating for universal healthcare, such as the founding of the National Health Service (NHS). Fleming’s principles echoed those of contemporaries like Nye Bevan, the architect of the NHS, emphasizing that access to life-saving medicines should not be limited by the ability to pay, (6)
SCANDAL While not exactly a scandal, there was controversy regarding who should receive the most credit for penicillin's development. Despite sharing the Nobel Prize with Howard Florey and Ernst Chain, their relationship was clouded by this issue. Fleming received more public recognition, partly because of the romantic narrative of his chance discovery and his greater willingness to engage with journalists. This led to what became known as "the Fleming myth," where he was portrayed as solely responsible for the development of penicillin. (7)
MILITARY RECORD Fleming was a member of the Territorial Army, serving from 1900 to 1914 in the London Scottish Regiment. During World War I, he served as a captain in the Army Medical Corps and was mentioned in dispatches for his service.
During the war, Fleming worked as a bacteriologist studying wound infections in a laboratory set up in a military hospital in Boulogne, France. Through his research there, he demonstrated that the use of strong antiseptics on wounds did more harm than good and recommended that wounds simply be kept clean with a mild saline solution.
HEALTH AND PHYSICAL FITNESS "A good gulp of hot whisky at bedtime-its not very scientific but it helps." Alexander Fleming when asked about a cure for colds.
HOMES Fleming was born and raised at Lochfield Farm near Darvel, Ayrshire, Scotland.
By 1901, Fleming had moved to London, residing with his elder brother Thomas and other siblings in York Street, St Marylebone.
During his early career at St Mary’s Hospital, he lived in a flat in St Marylebone, conveniently close to the hospital where he made his historic discovery of penicillin.
In later years, Fleming lived at 20a Danvers Street, Chelsea, London SW3 5AT. During World War II, it was hit by bombs in 1941, but he fortunately escaped unharmed. This address is commemorated with an English Heritage blue plaque, marking it as his home during the period when he was internationally celebrated for his scientific achievements.
Fleming also maintained a country home called "The Dhoon" (sometimes spelled "The Dhwon") in Barton Mills, Suffolk, East Anglia. This retreat is documented in multiple editions of Kelly’s Directory between 1922 and 1937.
TRAVEL After gaining worldwide recognition for his discovery of penicillin, Fleming traveled extensively overseas as a public ambassador for medicine and science. These travels took him to many countries where he was celebrated for his contributions to medical science.
DEATH Sir Alexander Fleming died suddenly of a heart attack (coronary thrombosis) at his home in Chelsea, London, on March 11, 1955. He had been experiencing what he thought was gastric discomfort for several weeks, but the fatal event came swiftly-his wife called their physician about his nausea, but Fleming died within minutes, as he had wished: "quietly, without a gradual decline in physical or mental capacity, and even without inconveniencing his physician".
A funeral service was held for Fleming at St. Paul's Cathedral, London, on March 18, 1955. The ceremony was attended by many dignitaries, colleagues, nurses, and members of the public, reflecting his immense impact on medicine and society. His widow, Lady Amalia Fleming, and other mourners followed the coffin, which contained his ashes in an urn, into the cathedral for the service.
His ashes are interred at St Paul's Cathedral alongside the tombs and memorials of other national British heroes such as Admiral Lord Nelson, the Duke of Wellington, and Florence Nightingale.
His final resting place is marked by a marble plaque in the northern aisle at the east end of the crypt, inscribed:
"Remember before God
Sir Alexander Fleming F.R.S.
discoverer of penicillin
whose ashes rest
beneath this plaque
Born 6 August 1881
Died 11 March 1955"
A terracotta tile with his initials "A. F." is set into the pavement beneath the plaque
APPEARANCES IN MEDIA Sir Alexander Fleming has enjoyed a surprisingly busy after‑life in the media, popping up everywhere from wartime newsreels to Google Doodles.
His screen debut came in 1939, when British and American newsreel companies filmed him in his laboratory at St Mary’s Hospital, calmly dripping raw penicillin onto Petri dishes to reassure both civilians and Allied soldiers that a potential miracle drug was on the way. Five years later, listeners heard the real Fleming on the BBC’s wildly popular panel show The Brains Trust; the broadcast generated more than ten thousand letters, many asking whether penicillin could cure everything from influenza to baldness.
In 1945 the UK government’s Crown Film Unit released an Oscar‑winning documentary short simply titled Penicillin. Fleming appears only fleetingly—most of the film celebrates the Oxford team who scaled up production—but his cameo helped cement the lone‑genius myth already forming around him. Hollywood took a stab in 1951 with The Magic Box, a biopic of early cinematographer William Friese‑Greene. The script shoehorned Fleming—played by Wolf Morris—into a scene in which he benevolently supplies penicillin to the dying pioneer, a touching if historically dubious episode.
Television soon followed. A 1958 episode of ITV’s Armchair Theatre used Fleming’s discovery as a grim counterpoint to nineteenth‑century surgical horrors, while a 1963 U.S. medical anthology, The Doctors and the Nurses, offered a thinly disguised version of him in the character “Dr Lennox,” complete with Scottish burr and cluttered workbench. The 1960s also brought philatelic fame: Royal Mail’s 1965 “Medical Discoveries” stamp set featured Fleming alongside Joseph Lister and Edward Jenner—the first time a living British scientist appeared on a UK postage stamp.
Print culture did its part. Gwyn Macfarlane’s 1971 bestseller Fleming: Discoverer of Penicillin entrenched the tidy narrative of accidental brilliance, a storyline later questioned by historians who highlighted the equally crucial roles of Howard Florey and Ernst Chain. The BBC revisited those doubts in 1988 with Penicillin: The Miracle and the Myths, a documentary that interviewed surviving lab assistants and cheerfully dismantled several romantic legends—including the notion that the fateful Petri dish sat beside an open window.
Dramatists and satirists kept the story alive. A 1999 Anglo‑Canadian feature, Happy Accidents, portrayed Fleming as a genial but overwhelmed mentor, while a 2000 BBC Radio 4 comedy‑doc, A Dirty Petri Dish, let a sentient mould narrate its own rise to fame—a cult favourite among microbiologists.
In the digital era Fleming continues to crop up. Google celebrated the 85th anniversary of the mould moment with an animated Doodle (August 6, 2013) showing penicillin plates chasing cartoon bacteria. A 2020 Radiolab podcast episode, The Fungus Among Us, spliced archival audio of Fleming into a story about wartime bed‑pan production lines and modern fermentation tech. Most recently, National Geographic’s 2023 series Limitless with Chris Hemsworth used a brisk montage of Fleming’s discovery to launch a discussion of antibiotic resistance and human longevity.
Across these appearances, a pattern emerges: early media painted Fleming as the heroic everyman whose accidental insight saved the world; later works reposition him as Act I in a larger ensemble, or as a cautionary emblem in the age of drug‑resistant superbugs. Yet whether he’s portrayed by actors, quoted in documentaries, or caricatured by Google, the image endures: a slightly rumpled Scotsman squinting at a dirty dish, nudging humanity toward its greatest medical victory.
ACHIEVEMENTS Discovery of lysozyme (1921)
Discovery of penicillin (1928)
Nobel Prize in Physiology or Medicine (1945)
Knighthood (1944)
Hunterian Professorship of the Royal College of Surgeons of England
Numerous honorary doctorates from universities around the world.
Fellow of the Royal Society (FRS) in 1943
In 1999, he was named in Time magazine's list of the 100 Most Important People of the 20th century.
In 2009, he was voted the third "greatest Scot" in an opinion poll conducted by STV, behind only Robert Burns and William Wallace.
Sources (1) Encyclopaedia of Trivia (2) National Library of Medicine (3) Deepfun (4) Nobelprize.org (5) Patheos (6) Radical Tea Towel (7) Britannica
Sunday, 26 January 2014
Paul Ehrlich
NAME Paul Ehrlich
WHAT FAMOUS FOR Pioneer in immunology and chemotherapy; Nobel laureate for his work on immunity; discovered Salvarsan, the first effective treatment for syphilis.
BIRTH Paul Ehrlich was born on March 14, 1854, in Strehlen in the Prussian province of Lower Silesia (now Strzelin in southwestern Poland).
FAMILY BACKGROUND Ehrlich was born into a Jewish family. His father, Ismar Ehrlich (1818-1898), was the leader of the local Jewish community, an innkeeper, a distiller of liqueurs, and the royal lottery collector in Strehlen. His mother was Rosa Weigert (1826-1909).
His grandfather, Heymann Ehrlich, had been a fairly successful distiller and tavern manager.
Paul Ehrlich was the cousin of Karl Weigert, a prominent pathologist who owned one of the first microtomes and significantly influenced Ehrlich's interest in tissue staining.
He had one sister, Anna Ehrlich (1857-1940).
CHILDHOOD During his childhood in Strehlen, Ehrlich developed a keen interest in science, particularly fascinated by the process of staining microscopic tissue sections, a skill he honed under the guidance of his cousin Karl Weigert. This early exposure laid the foundation for his later work in hematology.
EDUCATION Paul Ehrlich attended the time-honored secondary school Maria-Magdalenen-Gymnasium in Breslau, where he met Albert Neisser, who later became a colleague.
He pursued medical studies at several universities, including Breslau, Strasbourg, Freiburg im Breisgau, and Leipzig. In 1878, he obtained his doctorate of medicine with a dissertation titled "Contributions to the Theory and Practice of Histological Staining".
He completed his clinical education and habilitation at the prestigious Charité medical school in Berlin in 1886, with a thesis entitled "The Need of Organisms for Oxygen". (1)
CAREER RECORD 878: Began work at the Charité Hospital in Berlin as an assistant medical director.
1882: Developed staining techniques for identifying bacteria.
1890: Worked with Robert Koch at the Institute for Infectious Diseases in Berlin.
1896: Director of the newly founded Institute for Serum Research and Serum Testing in Steglitz, near Berlin.
1899: Institute moved to Frankfurt and became the Royal Prussian Institute for Experimental Therapy.
1906: Became director of the Georg Speyer House for Chemotherapy Research in Frankfurt.
1908: Awarded the Nobel Prize in Physiology or Medicine.
1914: Appointed full Professor of Pharmacology at the newly established Frankfurt University.
APPEARANCE Ehrlich was often depicted in portraits as a bearded man in late middle age, exuding a contemplative demeanor. He was known for his habit of smoking incessantly, consuming up to 25 strong cigars a day, and frequently carrying a box under one arm, which became a distinctive trait.
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| Paul Ehrlich |
FASHION As a 19th-century scientist, Ehrlich dressed in formal attire, such as suits and ties, typical of his professional and social standing.
CHARACTER Ehrlich was known for his persistence and determination in research. He often stated that to have success, one needed the 4 'Gs' (in German): Geld ("money"), Geduld ("patience"), Geschick ("skills"), and Glück ("luck").
After his breakthrough with Salvarsan, he humbly remarked: "for 7 years of misfortune, I had one moment of luck". This reflects both his modesty and perseverance in the face of repeated experimental failures. (2)
SPEAKING VOICE Ehrlich had a hasty manner of speech, often accompanied by gesticulations. He frequently used interjections and catchphrases, such as "Wissen Sie, verstehen Sie..." (you know, you understand), "Ja, natürlich, natürlich..." (Yes, certainly, certainly), and "Wundervoll... Grossartig!" (Wonderful... marvelous!). His Silesian accent was evident in his friendly greeting "Tag ook," pronounced with a hard 'g'.
SENSE OF HUMOUR His humor often manifested in his colorful expressions and wordplay, such as his invented term "Ungeschickter Taperkerl" (meaning an unskilled or awkward person).
RELATIONSHIPS In 1883, Paul Ehrlich married Hedwig Pinkus (1864-1948) in the synagogue in Neustadt (now Prudnik, Poland). Hedwig was 19 years old at the time of their marriage and was the sister of Max Pinkus, who owned a textile factory in Neustadt.
The couple had two daughters: Stephanie (1884-1966), who later married Ernst Schwerin (1869-1946), and Marianne (1886-1963).
Professionally, he collaborated with many scientists, but his relationship with Emil von Behring was strained, reflecting the personal dynamics behind scientific advancements.
MONEY AND FAME For a period, Ehrlich financed his research from his own funds and his wife's dowry. His father-in-law's position and understanding of Paul's scientific passion allowed him to equip a laboratory and continue his work even after losing his job.
Throughout his career, Ehrlich gained significant recognition in the scientific community. Upon his death, Wilhelm II, the German emperor, wrote in a telegram of condolence: "I, along with the entire civilized world, mourn the death of this meritorious researcher for his great service to medical science and suffering humanity; his life's work ensures undying fame and the gratitude of both his contemporaries and posterity".
FOOD AND DRINK Ehrlich had a habit of eating little, living largely on mineral water. His primary indulgence was smoking; he consumed 25 strong cigars a day, a practice noted by his contemporaries.
LITERATURE Ehrlich primarily focused on scientific literature, contributing extensively to medical journals.
NATURE Paul Ehrlich's primary hobby and interest was his scientific work, particularly in the field of biology. He was deeply fascinated by butterflies from a young age, which evolved into a broader interest in scientific issues. This passion for butterflies and nature continued throughout his life and career.
HOBBIES AND SPORTS Ehrlich was known for his intense focus on his work, often working around 80 hours per week, split between biology and policy issues. He considered his biology work as a form of vacation and tried to avoid time-wasting activities.
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| Paul Ehrlich around 1900 in his Frankfurt office |
SCIENCE AND MATHS From his youth, Ehrlich was drawn to Latin, mathematics, and especially chemistry. He had a remarkable ability to merge his knowledge of chemistry with biological theories to develop new concepts and approaches. He demonstrated little interest in subjects he did not find challenging, instead passionately focusing on scientific pursuits. This selective approach to learning continued throughout his education, as he reportedly disliked examinations and dedicated only minimum attention to subjects that did not capture his interest. (4)
Ehrlich made groundbreaking contributions to science, particularly in hematology, immunology, and chemotherapy, with his staining techniques and theories laying the foundation for modern medical diagnostics and treatments.
WORK Paul Ehrlich, a man who clearly had no patience for idle hands, earned his doctorate in 1882 and promptly set to work at Berlin’s Charité hospital under Theodor Frerichs, where he spent his time dabbling in histology, hematology, and—rather delightfully—color chemistry. One can only imagine the excitement of the early days, peering at stains and slides, uncovering the mysteries of the human body one vivid dye at a time.
Then came a rather inconvenient case of tuberculosis, which sidelined him for a bit, but Ehrlich, not one to let a near-death experience slow him down, bounced back in 1889 and set up a modest private practice and laboratory in Berlin-Steglitz. His reputation as a medical mind to watch soon caught the attention of none other than Robert Koch, who lured him to the Berlin Institute of Infectious Diseases in 1891. By 1896, Ehrlich was handed the reins of the newly minted Institute for Serum Research and Testing, which sounds like an exceptionally serious place filled with exceptionally serious people in lab coats.
The institute moved to Frankfurt in 1899, taking on the far grander title of the Institute of Experimental Therapy, where Ehrlich’s work really hit its stride. He became a full honorary professor at Göttingen in 1904 (a title that no doubt looked splendid on letterhead) and, two years later, took charge of the Georg Speyer House, where he would make the kind of discovery that places one permanently in the annals of medical history.
Ehrlich’s research career can be conveniently divided into three phases, much like a well-structured novel. The first was all about staining things—bacteria, tissues, anything that sat still long enough. He refined the Gram stain and developed a method to highlight the tubercle bacillus, which made him a hit with the bacteriologists of the day.
The second phase saw him pondering the grand mechanics of cellular interaction, leading to his "side-chain theory" of 1897. This was an elegant proposal suggesting that cells had specialized receptors that could latch onto certain molecules—a concept that eventually underpinned much of modern pharmacology, immunology, and hematology. More immediately, it also helped him develop standardized antiserum therapies, most notably an effective one against diphtheria.
Then came the third and most dramatic phase of his career: the quest for a magic bullet—an elusive, targeted drug that could attack disease without harming the host. Ehrlich and his team, including the indispensable Sahachiro Hata, tested no fewer than 300 compounds in what must have been a spectacularly frustrating exercise in scientific trial and error. But perseverance paid off, and in 1909, they finally struck gold (or, more accurately, arsenic) with compound 606, a treatment for syphilis that would go on to be marketed under the memorable name Salvarsan.
By 1914, Ehrlich had secured a full professorship at Frankfurt University, adding another line to his ever-growing list of titles. More importantly, his work had helped lay the foundation for modern chemotherapy, immunology, and pharmacology, proving that sometimes, if you stain enough slides, scribble enough theories, and test enough compounds, you might just change the world.
PHILOSOPHY & THEOLOGY As a secular Jew, his views were rooted in scientific rationalism. Ehrlich's work was guided by a belief in the power of chemistry to solve biological problems
POLITICS In 1914, Ehrlich signed the Manifesto of the Ninety-Three, which was a defense of Germany's World War I politics and militarism.
SCANDAL Paul Ehrlich's groundbreaking syphilis treatment, Salvarsan, was met with intense controversy and legal challenges due to fatalities during its clinical trials. Accusations of recklessness were leveled against him, with some claiming he 'stopped at nothing' in his pursuit of a cure. The turmoil reached a peak in 1914 when a leading critic was convicted of criminal libel, with Ehrlich testifying at the trial. Although exonerated, the ordeal profoundly impacted Ehrlich's mental health, contributing to a lasting depression.
The period, dubbed the 'Salvarsan Wars' by historians, saw Ehrlich and his associate, Sahachiro Hata, vilified for allegedly profiting from a dangerous drug. False claims, such as forced treatments on prostitutes at Frankfurt Hospital, further fueled the public outcry.
Despite this turbulent period, Salvarsan remained the world's primary syphilis treatment until the introduction of the less toxic and easier-to-administer Neosalvarsan in 1912. Both Salvarsan and Neosalvarsan remained standard treatments until the advent of penicillin in the 1940s."
HEALTH AND PHYSICAL FITNESS Ehrlich's health was not robust, and he was a heavy smoker. In 1888, he contracted tuberculosis, presumably during his laboratory work. He spent two years recovering in Egypt and Southern Europe with his wife before returning to Berlin to continue his work.
He experienced a slight stroke in 1914 and on August 17, 1915, Ehrlich suffered a heart attack, which led to his death a few days later.
HOMES After his marriage to Hedwig Pinkus, Ehrlich settled in the villa of the Fränkel family on Wiesenerstrasse in Neustadt. Later, when his institute moved to Frankfurt am Main in 1899, he relocated there.
TRAVEL In 1888-1889, Ehrlich traveled to Egypt and other countries to recover from tuberculosis. His education and career required travel between various German universities and research institutions, including Breslau, Strasbourg, Freiburg, Leipzig, Berlin, and Frankfurt.
DEATH Paul Ehrlich died on August 20, 1915, in Bad Homburg vor der Höhe, Germany, at the age of 61, following a heart attack that he had suffered three days earlier.
Ehrlich was buried in the Old Jewish Cemetery (Alter Jüdischer Friedhof) on Rat-Beil-Strasse in Frankfurt am Main, Germany. His tomb is located in Sector 114 of the cemetery. Ehrlich's daughter Marianne is buried near him in the same cemetery. The tombstone bears the inscription "GEB 14 MARZ 1854 / GEST 20 AUGUST 1915" in German, indicating his birth and death dates
APPEARANCES IN MEDIA His life and work have been depicted in various documentaries and historical accounts of medical history.
Ehrlich was portrayed by Edward G. Robinson in the 1940 film Dr. Ehrlich's Magic Bullet, a Hollywood biopic that highlighted his scientific achievements and life, reflecting his cultural impact.
ACHIEVEMENTS Nobel Prize in Physiology or Medicine (1908).
Discovery of Salvarsan (arsphenamine).
Development of staining techniques for microscopy.
Formulation of the side-chain theory of immunity.
Founding and direction of significant research institutes
Sources (1) Nobelprize.org (2) National Library of Medicine (3) University of Silesia (4) Archives of Pathology & Laboratory Medicine
Sunday, 17 March 2013
Francis Crick
NAME Francis Harry Compton Crick
WHAT FAMOUS FOR Francis Crick is renowned for his co-discovery of the DNA double helix, a milestone in molecular biology.
BIRTH Born on June 8, 1916, in Northampton, England.
FAMILY BACKGROUND Francis Crick was the elder son of Harry and Annie Elizabeth Crick (née Wilkins. His father and uncle ran a family boot and shoe factory. While Crick had a younger brother, A. F. who became a doctor, a more significant influence came from his grandfather, Walter Drawbridge Crick. An amateur naturalist, Walter nurtured Francis's scientific curiosity.
CHILDHOOD From a young age, Francis exhibited a strong interest in science. He devoured books on the subject and was fortunate to have his uncle Walter nearby. In a dedicated shed, Walter imparted various scientific skills to young Francis, including glass blowing, chemical experiments and making photographic prints. This early exposure to hands-on science undoubtedly shaped Crick's future path. Notably, by the age of 12, he had abandoned religious beliefs, preferring a scientific lens to understand the world.
EDUCATION Crick's formal education began at Northampton Grammar School, followed by a scholarship to the prestigious Mill Hill School in London at age 14. Here, he excelled in science subjects like mathematics, physics, and chemistry, even winning the Walter Knox Prize for Chemistry.
He continued his academic journey at University College London, obtaining a B.Sc. in physics in 1937. While he initially started postgraduate research under Prof E. N. da C. Andrade, World War II intervened, forcing a temporary shift in his focus.
After the war, Crick transitioned to biology, pursuing his Ph.D. at Cambridge University's Caius College. He completed his doctorate in 1954, focusing on X-ray diffraction of polypeptides and proteins. This transition from physics to biology proved to be pivotal, laying the groundwork for his groundbreaking collaboration with James Watson on the structure of DNA.
CAREER RECORD During World War II, he worked for the British Admiralty,
In 1951, Crick began working with James Watson at the Cavendish Laboratory in Cambridge. Their collaboration, along with contributions from Rosalind Franklin and Maurice Wilkins, led to the identification of DNA's helical structure. Their pivotal work on DNA's structure was announced on February 28, 1953, in the Eagle pub near Cambridge's Cavendish Laboratory.
Crick and Watson's working style was characterized by candid communication, intense discussions, and a theoretical focus. They were not afraid to challenge each other's ideas, often engaging in heated debates both in their office and at the nearby Eagle pub. While they did not conduct experiments themselves, they excelled at interpreting and integrating the data of other researchers.
In 1977, Crick joined the Salk Institute for Biological Studies in La Jolla, California, as a research professor.
APPEARANCE See photo below
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| Francis Crick in his office. By Francis_Crick.png: Photo: Marc Liebermanderivative |
FASHION Crick was known to be always careful and well-groomed in his dress, usually wearing a colorful tie.
CHARACTER Crick was described as driven, intellectually curious, and highly competitive, with a youthful arrogance and impatience with sloppy thinking.
SENSE OF HUMOUR Throughout his life, Crick maintained a balance between being a serious, committed scientist and someone with a playful, sometimes flippant personality. In the early 1970s, Peter Medawar suggested that Crick recast an essay he had written with Leslie Orgel about the origins of life for the fashion magazine Vogue. In response to this suggestion, Crick humorously quipped that they had originally considered Playboy magazine instead.
Crick’s sharp wit often shone in conversations. He once quipped that scientific breakthroughs require “ruthlessness” and “impatience with nonsense.”
RELATIONSHIPS Francis Crick was married twice. His first marriage was to Ruth Doreen Dodd whom he wed on February 18, 1940. They had one child together, Michael. The marriage ended in divorce on May 8, 1947.
On August 14, 1949, Crick married French artist Odile Speed. This marriage lasted until his death in 2004. With Odile, Crick had two daughters: Gabrielle and Jacqueline.
Odile, was an artist who famously drew the illustration of the double helix structure of DNA for Crick and Watson's groundbreaking paper in Nature in 1953. The Cricks were known for hosting lively parties in Cambridge and later in California, where they moved in the 1970s when Francis Crick became a professor at the Salk Institute.
Francis Crick and James Watson were drawn together by their shared fascination with DNA and the groundbreaking work of scientists like Linus Pauling. Their mutual intellectual curiosity formed the bedrock of their partnership.
Their collaboration was fueled by a blend of complementary traits: youthful arrogance, ruthlessness, and impatience with sloppy thinking. This combination of qualities allowed them to tackle the complex puzzle of DNA structure with unwavering determination.
MONEY AND FAME Crick received global recognition and numerous accolades, including a Nobel Prize in 1962, but remained focused on scientific discovery rather than wealth.
Below is a stained glass window in the dining hall of Caius College, in Cambridge, commemorating Francis Crick and representing the double helical structure of B-DNA. The stained glass was designed by Maria McClafferty and installed between 1992 and 1993
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| By Wikipedia user: Schutz |
FOOD AND DRINK Crick was known to enjoy a hearty meal and often dined in the company of colleagues, discussing scientific theories.
Crick and his wife Odile enjoyed champagne on special occasions. When they learned about his Nobel Prize win, Odile rushed to get ice to cool champagne for a celebration.
The Cricks were renowned for their lively social gatherings. They hosted parties at their home, the Golden Helix, in Cambridge, which often featured champagne and entertaining conversations. Later, in the 1960s, their parties became more bohemian and wild.
MUSIC AND ARTS Crick appreciated Odile’s artistic talents and supported her creative pursuits, which included painting and teaching. While not an artist himself, Crick had a fine sense of aesthetic elegance, reflected in his scientific discoveries and writing. He enjoyed the company of artists and creative individuals at their social gatherings
LITERATURE He enjoyed reading extensively, particularly scientific texts and philosophical works.
NATURE Crick was fascinated by the origins of life, even hypothesizing that life on Earth might have arrived via an unmanned rocket carrying microbial spores from an advanced civilization.
HOBBIES AND SPORTS Crick enjoyed intellectual hobbies, including chess and philosophical debates.
SCIENCE AND MATHS In the grand and occasionally haphazard saga of scientific discovery, few moments shine as brightly—or come with as many footnotes of controversy—as James D. Watson and Francis Crick’s unmasking of DNA’s structure in 1953. Their revelation of the double helix was, to put it mildly, a rather big deal. It fundamentally changed how we understand life itself, which is no small accomplishment for two men tinkering with metal models in a Cambridge lab.
The tale begins in 1951 at the Cavendish Laboratory, where Watson, a young and enthusiastic American, joined forces with Crick, a brash and brilliant Brit who, at the age of 35, had not yet completed his PhD but had plenty of opinions to make up for it. They made an unlikely but effective pair—Watson brought an unfiltered enthusiasm for the problem, while Crick had a penchant for grand theories and a voice that, according to colleagues, could carry across entire buildings.
Now, contrary to the neat and tidy version of history often told, Watson and Crick did not pull their discovery out of thin air. They leaned heavily—some might say rather too heavily—on the work of others, particularly Rosalind Franklin and Maurice Wilkins at King's College London. Franklin, a meticulous scientist, had produced astonishing X-ray diffraction images of DNA, most notably the now-famous "Photograph 51." This image, which vividly suggested a helical structure, found its way to Watson without Franklin's knowledge—an ethical footnote that historians and biographers have debated ever since.
Armed with Franklin’s data (whether they should have been or not), Watson and Crick embarked on an ambitious exercise in model-building, assembling DNA’s structure with metal plates and wire, as if life’s blueprint were some particularly tricky bit of Meccano. They soon arrived at their now-famous conclusion: DNA was not a single spiral, as some had suspected, but a double helix—a gloriously twisted ladder in which the rungs were formed by specific base pairings: adenine with thymine, guanine with cytosine, held together by delicate hydrogen bonds.
On April 25, 1953, their findings appeared in Nature under the unassuming title "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid." It was, as scientific papers go, astonishingly short—barely a page and a half—but its impact was seismic. The discovery explained, with almost poetic simplicity, how genetic information could be copied and passed down through generations, providing the missing key to the mystery of heredity.
Recognition followed, albeit unevenly. In 1962, Watson, Crick, and Wilkins were awarded the Nobel Prize in Physiology or Medicine. Franklin, who had tragically died of cancer in 1958 at just 37, was ineligible under the Nobel committee’s rules, which do not allow posthumous awards. This remains one of the great injustices of scientific history, though her contributions are now widely acknowledged.
The double helix has since become one of the most iconic images in all of science, its influence reaching far beyond genetics into medicine, biotechnology, forensics, and even popular culture. All of which makes it easy to forget that this revolutionary discovery was, at its heart, the result of two audacious minds, a bit of inspired guesswork, and an arguably ill-gotten photograph.
PHILOSOPHY & THEOLOGY By the age of 12, Crick had abandoned religious beliefs, preferring a scientific lens to understand the world.
As an avowed atheist, Crick dismissed conventional religion, focusing instead on scientific explanations for life's origins.
POLITICS Crick was outspoken about the ethical implications of scientific discoveries but avoided overt political affiliations.
SCANDAL Crick’s atheism was considered controversial, particularly as he worked in the Cavendish Laboratory, which bore a biblical inscription: “Great are the works of the Lord.”
During a celebration of Crick's Nobel Prize win, there was an incident involving fireworks. A policeman arrived at Crick's home to investigate a complaint that the noise was disturbing a neighbor's greyhounds.
MILITARY RECORD During World War II, Crick worked for the Admiralty Research Laboratory, where he helped design an undetectable mine for the Royal Navy.
HEALTH AND PHYSICAL FITNESS Crick remained active throughout his life, maintaining a sharp mind and keen energy for scientific work.
HOMES After joining the Medical Research Council Unit in 1949, Crick and his wife, Odile, settled in Cambridge. They initially made do with a small, austere flat, reflecting their modest circumstances. Later, they moved to a more comfortable home at 19 Portugal Place, affectionately known as "The Golden Helix." This house became renowned for the lively parties the Cricks hosted, drawing in a vibrant mix of scientists and intellectuals.
In the late 1970s, the Cricks embarked on a new chapter, relocating to California when Francis accepted a distinguished professorship at the Salk Institute. They divided their time between two homes: a suburban hilltop residence in La Jolla and a desert retreat.
TRAVEL Crick traveled widely, presenting lectures and collaborating with international researchers.
DEATH Francis Crick passed away on July 28, 2004, in San Diego, California, at the age of 88. His death came after he had been diagnosed with colon cancer.
Crick spent his last days at the University of California, San Diego (UCSD) Thornton Hospital in La Jolla, where he ultimately succumbed to his illness.
Following his death, Crick's body was cremated. In accordance with his wishes, his ashes were scattered in the Pacific Ocean. This choice of final resting place reflects Crick's connection to California, where he had lived and worked for many years at the Salk Institute for Biological Studies.
APPEARANCES IN MEDIA Crick and Watson's DNA discovery has been depicted in various documentaries, and films, cementing their legacy in popular culture.
The Race for the Double Helix (1987) is a BBC drama, starring Jeff Goldblum as James Watson and Tm Pigott-Smith as Francis Crick, portrays the events leading up to the discovery of the DNA structure.
Crick occasionally participated in televised discussions and lectures, sharing his insights on genetics and the origins of life.
ACHIEVEMENTS Co-discovery of the DNA double helix.
Nobel Prize in Physiology or Medicine in 1962, shared with James Watson and Maurice Wilkins.
Major contributions to the understanding of genetic coding and molecular biology.















